Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 10/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PLAT | P00750 | 2/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 2/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294689 | 1.00 | F2 (0.47) | F2GAAPLATPLAUPLG | |
| SCHEMBL8720064 | 0.97 | F2 (0.50) | F2PLATPLGF10PRSS1 | |
| SCHEMBL8717231 | 0.96 | F2 (0.51) | F2PLATPLGF10PRSS1 | |
| SCHEMBL8719611 | 0.96 | F2 (0.51) | F2PLATPLGF10PRSS1 | |
| SCHEMBL7302360 | 0.90 | ACACB (0.45) | F2GAAPLATPLAUPLG | |
| SCHEMBL8717263 | 0.89 | ADAMTS4 (0.47) | F2 | |
| SCHEMBL7332989 | 0.87 | F2 (0.47) | F2PLATPLGF10PRSS1 | |
| SCHEMBL7332615 | 0.87 | F2 (0.49) | F2PLATPLGF10PRSS1 | |
| SCHEMBL8716462 | 0.86 | GAA (0.49) | F2GAAPLATPLGF10 | |
| SCHEMBL8719583 | 0.86 | F2 (0.48) | F2PLATPLGF10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5536867-A | Process for the manufacture of dicarboxamides | HOFFMANN-LA ROCHE INC. (US) | 1996-07-16 | — | — | US | claimed |
| EP-0684238-A2 | Process for the manufacture of dicarboxamides | F. HOFFMANN-LA ROCHE AG (CH) | 1995-11-29 | — | — | EP | claimed |
| EP-0684238-A2 | Process for the manufacture of dicarboxamides | F. HOFFMANN-LA ROCHE AG (CH) | 1995-11-29 | — | — | EP | disclosed |