Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 14/20 | 0.44 |
| ▸ | MMP9 | P14780 | 11/20 | 0.44 |
| ▸ | MMP13 | P45452 | 5/20 | 0.44 |
| ▸ | MMP1 | P03956 | 4/20 | 0.44 |
| ▸ | MMP3 | P08254 | 4/20 | 0.44 |
| ▸ | MMP7 | P09237 | 3/20 | 0.44 |
| ▸ | MMP8 | P22894 | 4/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7335977 | 0.90 | MMP13 (0.43) | ADAMTS4F2MMP2MMP9MMP13 | |
| SCHEMBL7294689 | 0.89 | F2 (0.47) | F2 | |
| SCHEMBL9004947 | 0.89 | F2 (0.47) | F2 | |
| SCHEMBL8716303 | 0.89 | EEF2K (0.46) | ADAMTS4MMP2MMP9MMP13MMP1 | |
| SCHEMBL8721787 | 0.89 | EEF2K (0.46) | ADAMTS4MMP2MMP9MMP13MMP1 | |
| SCHEMBL8720064 | 0.86 | F2 (0.50) | F2 | |
| SCHEMBL8717231 | 0.86 | F2 (0.51) | F2 | |
| SCHEMBL8719611 | 0.85 | F2 (0.51) | F2 | |
| SCHEMBL8719561 | 0.84 | F2 (0.44) | F2 | |
| SCHEMBL7330308 | 0.80 | ALDH1A1 (0.42) | F2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763604-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| US-5677448-A | CHEMICAL INTERMEDIATES FOR MAKING ANTAGONIST OF THROMBIN, TREATING THROMBOSIS, STROKE, INFLAMMATION, ARTERIOSCLEROSIS, CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1997-10-14 | — | — | US | disclosed |
| US-5578594-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5405854-A | Anticoagulants | HOFFMANN-LA ROCHE INC. (US) | 1995-04-11 | — | — | US | disclosed |