Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4492754 | 0.74 | SOAT1 (0.47) | SOAT1GAAALDH1A1LMNANPSR1 | |
| SCHEMBL9000543 | 0.73 | ALDH1A1 (0.49) | SOAT1NPC1RAB9AGAAALDH1A1 | |
| SCHEMBL14565845 | 0.73 | SOAT1 (0.46) | SOAT1GAAALDH1A1LMNACYP1A2 | |
| SCHEMBL4985295 | 0.72 | SOAT1 (0.50) | SOAT1GAAHPGDCYP1A2CYP3A4 | |
| SCHEMBL32667998 | 0.71 | CYP1A2 (0.50) | SOAT1RAB9AALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL9008115 | 0.69 | SOAT1 (0.39) | SOAT1NPC1RAB9ANPSR1CYP1A2 | |
| SCHEMBL8325945 | 0.69 | SOAT1 (0.47) | SOAT1NPC1RAB9AGAAALDH1A1 | |
| SCHEMBL8326103 | 0.69 | SOAT1 (0.47) | SOAT1NPC1RAB9AGAAALDH1A1 | |
| SCHEMBL9000830 | 0.68 | SOAT1 (0.39) | SOAT1NPC1RAB9AGAAALDH1A1 | |
| SCHEMBL9000761 | 0.68 | SOAT1 (0.39) | SOAT1NPC1RAB9AALDH1A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |