SCHEMBL900558

SCHEMBL900558

COc1ccnc(-c2cccc3c2ncn3CC(F)(F)F)c1

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 5/20 0.55
CYP1A2 P05177 1/20 0.55
CCR1 P32246 1/20 0.42
CCR5 P51681 1/20 0.42
CCR8 P51685 1/20 0.42
P2RX7 Q99572 3/20 0.38
CDYL2 Q8N8U2 1/20 0.37
CDYL Q9Y232 1/20 0.37
CDY1; CDY1B Q9Y6F8 1/20 0.37
PDE8A O60658 1/20 0.35
PDE10A Q9Y233 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MKNK2 Q9HBH9 2/20 0.35
YTHDC1 Q96MU7 1/20 0.34
METAP2 P50579 1/20 0.34
CDK1 P06493 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL900105 0.75 CYP17A1 (0.73) CYP17A1CYP1A2
SCHEMBL900497 0.71 CYP17A1 (1.00) CYP17A1CYP1A2
SCHEMBL903225 0.69 CYP17A1 (0.70) CYP17A1CYP1A2PDE10A
SCHEMBL903217 0.68 CYP17A1 (1.00) CYP17A1CYP1A2METAP2
SCHEMBL900104 0.68 CYP17A1 (1.00) CYP17A1CYP1A2METAP2
SCHEMBL30119632 0.68 CYP17A1 (0.60) CYP17A1CYP1A2L3MBTL1YTHDC1
SCHEMBL28634932 0.68 CYP17A1 (0.48) CYP17A1CYP1A2METAP2
SCHEMBL20216043 0.67 P2RX7 (0.60) CYP1A2CCR1CCR5CCR8P2RX7
SCHEMBL903166 0.67 CYP17A1 (0.53) CYP17A1CYP1A2
SCHEMBL900219 0.67 CYP17A1 (0.71) CYP17A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2621913-A1 SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS Bristol-Myers Squibb Company (US) 2013-08-07 EP disclosed
WO-2012044537-A1 SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2012-04-05 WO disclosed