SCHEMBL9006032

SCHEMBL9006032

O=CN(CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1)Cc1cccnc1

nearest known ligand 0.54

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 20/20 0.54
CACNA1F O60840 3/20 0.54
CACNA1D Q01668 3/20 0.54
CACNA1S Q13698 3/20 0.54
CACNA1C Q13936 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8911081 0.80 TACR1 (0.64) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8911255 0.76 TACR1 (0.69) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8965330 0.76 TACR1 (0.69) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8912893 0.73 TACR1 (0.84) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL9434738 0.72 SLC1A5 (0.46) TACR1
SCHEMBL8911166 0.71 TACR1 (0.71) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8827093 0.71 TACR1 (0.80) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8827091 0.71 TACR1 (0.80) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL13891612 0.71 TACR1 (1.00) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8911425 0.71 TACR1 (0.68) TACR1CACNA1FCACNA1DCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5554633-A ANTIINFLAMMATORY, ANTIARTHRITIC, AND ANALGESIC AGENTS; MIGRAINE MERCK, SHARP & DOHME, LTD. (GB) 1996-09-10 US disclosed
WO-1994003429-A1 SUBSTITUTED AMINES AS TACHYKININ RECEPTOR ANTAGONISTS MERCK SHARP & DOHME LIMITED (GB) 1994-02-17 WO disclosed