SCHEMBL9006928

SCHEMBL9006928

CC1(C)CCOc2cc(SC#C[Si](C)(C)C)ccc21

nearest known ligand 0.33

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
RARA P10276 3/20 0.33
RARB P10826 3/20 0.33
RARG P13631 3/20 0.33
MAP3K14 Q99558 2/20 0.32
CYP26A1 O43174 2/20 0.32
CYP26B1 Q9NR63 1/20 0.32
RXRA P19793 1/20 0.32
HNF4A P41235 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9006914 0.83 RARB (0.35) RARARARBRARGMAP3K14CYP26A1
SCHEMBL6668402 0.77 RARA (0.32) RARARARBRARGCYP26A1CYP26B1
SCHEMBL7713129 0.77 RARB (0.36) RARARARBRARGMAP3K14CYP26A1
SCHEMBL9007018 0.75 KCNH2 (0.36)
SCHEMBL6670543 0.74 MAP3K14 (0.43) RARARARBRARGMAP3K14CYP26A1
SCHEMBL9185941 0.72 RARB (0.44) RARARARBRARGMAP3K14CYP26A1
SCHEMBL6668122 0.72 MAP3K14 (0.39) RARARARBRARGMAP3K14CYP26A1
SCHEMBL4370337 0.71 RARB (0.43) RARARARBRARGMAP3K14CYP26A1
SCHEMBL6664711 0.70 MAP3K14 (0.37) RARARARBRARGMAP3K14CYP26A1
SCHEMBL9175999 0.70 AKR1B1 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0571546-B1 CHROMAN AND THIOCHROMANS WITH PHENYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY ALLERGAN INC (US) 1996-10-16 EP disclosed
US-5346915-A Chromans and thiochromans with phenylethynyl substituents at the 7-position having retinold-like biological activity ALLERGAN, INC. (US) 1994-09-13 US disclosed
US-5346895-A Treating dermatoses, immunological disorders, wound healing ALLERGAN, INC. (US) 1994-09-13 US disclosed
EP-0571546-A1 CHROMAN AND THIOCHROMANS WITH PHENYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY. ALLERGAN INC (US) 1993-12-01 EP disclosed
WO-1992017471-A1 CHROMANS AND THIOCHROMANS WITH HETEROARYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY ALLERGAN, INC. (US) 1992-10-15 WO disclosed
WO-1992014725-A1 CHROMAN AND THIOCHROMANS WITH PHENYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY ALLERGAN, INC. (US) 1992-09-03 WO disclosed