SCHEMBL9008495

SCHEMBL9008495

Fc1cc(-c2c(F)cc(Br)cc2F)cc(F)c1OC(F)(F)F

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.31
GRIA1 P42261 1/20 0.31
CACNG8 Q8WXS5 1/20 0.31
FFAR1 O14842 1/20 0.30
FFAR4 Q5NUL3 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6558034 0.88 MAPT (0.36) MAPT
SCHEMBL9013332 0.86 MAPT (0.35) MAPT
SCHEMBL16707066 0.80 FFAR1 (0.35) GRIA1CACNG8FFAR1FFAR4
SCHEMBL30509771 0.77 ALOX5AP (0.41) FFAR1FFAR4
SCHEMBL22440615 0.77 ALOX5AP (0.41) FFAR1FFAR4
SCHEMBL8005244 0.77 PDE2A (0.43) GRIA1CACNG8
SCHEMBL28819149 0.76 MAPT (0.36) MAPT
SCHEMBL8018948 0.74 MAPT (0.31) MAPT
SCHEMBL8022531 0.74 DHODH (0.30)
SCHEMBL9417611 0.73 CES2 (0.32) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5582764-A Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-12-10 US disclosed
EP-0670322-A1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it Shin-Etsu Chemical Co., Ltd. (JP) 1995-09-06 EP disclosed