SCHEMBL6558034

SCHEMBL6558034

Fc1cc(Br)cc(F)c1OC(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.36
PDE2A O00408 1/20 0.32
NOTUM Q6P988 1/20 0.32
GPR3 P46089 1/20 0.31
EPHX2 P34913 1/20 0.31
KMT2A Q03164 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9013332 0.98 MAPT (0.35) MAPTPDE2ANOTUMGPR3EPHX2
SCHEMBL9008495 0.88 MAPT (0.31) MAPT
SCHEMBL28819149 0.86 MAPT (0.36) MAPTNOTUMKMT2A
SCHEMBL7767195 0.82 MAPT (0.41) MAPTPDE2ANOTUMKMT2A
SCHEMBL9804244 0.82 MAPT (0.34) MAPTNOTUM
SCHEMBL12736297 0.80 GPR3 (0.33) PDE2AGPR3EPHX2
SCHEMBL22440615 0.80 ALOX5AP (0.41) GPR3
SCHEMBL30509771 0.80 ALOX5AP (0.41) GPR3
SCHEMBL6684061 0.77 MAPT (0.35) MAPTKMT2A
SCHEMBL7772178 0.76 GRIN2B (0.33) NOTUMGPR3EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119039115-A Preparation method of 2, 6-difluoro-4-bromotrifluoromethoxybenzene 大连奇凯医药科技有限公司 2024-11-29 CN claimed
CN-117164436-A Method for synthesizing polyfluorophenol by lanthanum cerium copper catalysis 浙江大学衢州研究院 2023-12-05 CN claimed
CN-117024254-A Synthesis method of polyfluorophenol 浙江大学衢州研究院 2023-11-10 CN claimed
CN-102531854-B Synthesis method for 4-bromo-2, 6-difluoro-trifluoromethoxybenzene Hebei tonghua chemical co ltd 2014-05-28 CN claimed
JP-11080064-A None JP disclosed
US-20260085069-A1 PRODRUGS CAMBRIDGE ENTPR LTD (GB) 2026-03-26 US disclosed
EP-4584268-A1 PRODRUGS Cambridge Enterprise Limited (GB) 2025-07-16 EP disclosed
EP-4584265-A1 NOVEL COMPOUNDS, COMPOSITIONS AND THERAPEUTIC USES THEREOF Cambridge Enterprise Limited (GB) 2025-07-16 EP disclosed
CN-119039115-A Preparation method of 2, 6-difluoro-4-bromotrifluoromethoxybenzene 大连奇凯医药科技有限公司 2024-11-29 CN disclosed
CN-119039115-A Preparation method of 2, 6-difluoro-4-bromotrifluoromethoxybenzene 大连奇凯医药科技有限公司 2024-11-29 CN disclosed
CN-119039115-A Preparation method of 2, 6-difluoro-4-bromotrifluoromethoxybenzene 大连奇凯医药科技有限公司 2024-11-29 CN disclosed
CN-111170984-B Liquid crystal compound 默克专利股份有限公司 2024-09-10 CN disclosed
EP-0649454-A1 BENZENE DERIVATIVES AND LIQUID-CRYSTAL MEDIUM MERCK PATENT GmbH (DE) 1995-04-26 EP disclosed
WO-1995004790-A1 2-FLUOROCYCLOHEXENE DERIVATIVES MERCK PATENT GMBH (DE) 1995-02-16 WO disclosed
WO-1994026838-A1 BENZENE DERIVATIVES AND LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 1994-11-24 WO disclosed
EP-0568040-A1 Cyclohexane derivative and liquid crystal composition containing the same CHISSO CORPORATION (JP) 1993-11-03 EP disclosed
EP-0240121-B1 DIPHENYL ETHER DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-04-17 EP disclosed
EP-0390228-A2 Chemical intermediates IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-10-03 EP disclosed
US-4791139-A Diphenyl ether derivatives and their use as insecticides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-12-13 US disclosed
EP-0240121-A2 Diphenyl ether derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-10-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260085069-A1 PRODRUGS CSNK1A1, CSNK1G1, CSNK1D MAPT 1521/4885PDE2A 1313/4885NOTUM 4176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.