Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MME | P08473 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.52 |
| ▸ | TARS1 | P26639 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL900959 | 1.00 | KMT2A (0.58) | KMT2AALDH1A1CYP3A4MMEMEN1 | |
| Trifluoroacetic Acid SCHEMBL14762492 | 0.91 | ALDH1A1 (0.56) | KMT2AALDH1A1CYP3A4MMEMEN1 | |
| SCHEMBL1790982 | 0.88 | KMT2A (0.59) | KMT2AALDH1A1CYP3A4MMEMEN1 | |
| SCHEMBL4743536 | 0.88 | KMT2A (0.59) | KMT2AALDH1A1CYP3A4MMEMEN1 | |
| SCHEMBL13592564 | 0.88 | KMT2A (0.59) | KMT2AALDH1A1CYP3A4MMEMEN1 | |
| Trifluoroacetic Acid SCHEMBL15284646 | 0.88 | ALDH1A1 (0.49) | KMT2AALDH1A1CYP3A4MMEMEN1 | |
| Trifluoroacetic Acid SCHEMBL15284644 | 0.88 | ALDH1A1 (0.49) | KMT2AALDH1A1CYP3A4MMEMEN1 | |
| SCHEMBL2236118 | 0.84 | KMT2A (0.63) | KMT2AALDH1A1CYP3A4MMEMEN1 | |
| SCHEMBL1790978 | 0.84 | KMT2A (0.63) | KMT2AALDH1A1CYP3A4MMEMEN1 | |
| SCHEMBL6461987 | 0.84 | KMT2A (0.63) | KMT2AALDH1A1CYP3A4MMEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621508-B1 | N-CARBOXYALKYL AURISTATINS AND THE USE THEREOF | SEATTLE GENETICS INC (US) | 2015-08-26 | — | — | EP | disclosed |
| EP-2621508-A1 | N-CARBOXYALKYL AURISTATINS AND THE USE THEREOF | Seattle Genetics, Inc. (US) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012041805-A1 | N-CARBOXYALKYL AURISTATINS AND THE USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-04-05 | — | — | WO | disclosed |