Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | HNF4A | P41235 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.30 |
| ▸ | RARA | P10276 | 2/20 | 0.30 |
| ▸ | RARB | P10826 | 2/20 | 0.30 |
| ▸ | RARG | P13631 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8089535 | 0.81 | MAP3K14 (0.47) | MAP3K14NR3C1RXRAHNF4A | |
| SCHEMBL6669631 | 0.81 | MAP3K14 (0.43) | MAP3K14CYP26A1CYP26B1RXRAHNF4A | |
| SCHEMBL8089568 | 0.77 | ITGB2 (0.41) | MAP3K14NR3C1SMN1; SMN2 | |
| SCHEMBL5835328 | 0.77 | RARA (0.40) | MAP3K14CYP26A1CYP26B1RXRAHNF4A | |
| SCHEMBL2632863 | 0.72 | ITGB2 (0.46) | MAP3K14CYP26A1CYP26B1RXRASMN1; SMN2 | |
| SCHEMBL6124712 | 0.71 | MAP3K14 (0.39) | MAP3K14NR3C1SMN1; SMN2 | |
| SCHEMBL6668106 | 0.70 | MAP3K14 (0.41) | MAP3K14CYP26A1CYP26B1RXRAHNF4A | |
| SCHEMBL6667725 | 0.68 | SKP2 (0.41) | MAP3K14CYP26A1CYP26B1RXRAHNF4A | |
| SCHEMBL8293244 | 0.68 | RARA (0.49) | CYP26A1CYP26B1RXRAHNF4ARARA | |
| SCHEMBL22326839 | 0.67 | MAP3K14 (0.43) | MAP3K14SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0740665-A1 | PROCESS FOR PREPARING 4,4-DIALKYL-6-HALO-CHROMANS OR THIOCHROMANS USEFUL AS PHARMACEUTICAL INTERMEDIATES | Allergan (US) | 1996-11-06 | — | — | EP | disclosed |
| WO-1995019973-A2 | PROCESS FOR PREPARING 4,4-DIALKYL-6-HALO-CHROMANS OR THIOCHROMANS USEFUL AS PHARMACEUTICAL INTERMEDIATES | ALLERGAN (US) | 1995-07-27 | — | — | WO | disclosed |