SCHEMBL9009689

SCHEMBL9009689

CCCCCCCCCCCC1=NC(C)CN1

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.33
PKM P14618 1/20 0.33
HPGD P15428 1/20 0.33
KCNH2 Q12809 1/20 0.32
FUT7 Q11130 1/20 0.32
NOS1 P29475 3/20 0.32
NOS2 P35228 3/20 0.32
NOS3 P29474 2/20 0.32
NAAA Q02083 3/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11135927 1.00 ALDH1A1 (0.33) ALDH1A1PKMHPGDKCNH2FUT7
SCHEMBL11463750 1.00 ALDH1A1 (0.33) ALDH1A1PKMHPGDKCNH2FUT7
SCHEMBL9787943 1.00 ALDH1A1 (0.33) ALDH1A1PKMHPGDKCNH2FUT7
SCHEMBL10616810 1.00 ALDH1A1 (0.33) ALDH1A1PKMHPGDKCNH2FUT7
SCHEMBL11653482 1.00 ALDH1A1 (0.33) ALDH1A1PKMHPGDKCNH2FUT7
SCHEMBL11467223 0.92 EPHX2 (0.38) ALDH1A1
SCHEMBL11467225 0.92 EPHX2 (0.38) ALDH1A1
Hydrochloric Acid SCHEMBL2422211 0.90
SCHEMBL1741640 0.81 ALDH1A1 (0.33) ALDH1A1PKMHPGDKCNH2NAAA
SCHEMBL10617495 0.81 ALDH1A1 (0.33) ALDH1A1PKMHPGDKCNH2NAAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4876249-A TOPICAL; TRANSDERMAL, SYSTEMIC; FLUOCINOLINE ACETONIDE AND IMIDAZOLINE OR OXAZOLINE PENETRATION ENHANCER MIXTURE; THERAPEUTIC DRUGS THERAPEUTIC PATCH RESEARCH N.V. 1989-10-24 US claimed
EP-0296199-A1 HETEROCYCLIC COMPOUNDS FOR TRANSDERMAL USE RAJADHYAKSHA, Vithal J. (US) 1988-12-28 EP claimed
WO-1988004938-A1 HETEROCYCLIC COMPOUNDS FOR TRANSDERMAL USE RAJADHYAKSHA VITHAL J (US) 1988-07-14 WO claimed
EP-0622357-B1 Process for the production of cyclic amidine LION AKZO COMPANY LIMITED (JP) 1996-11-06 EP disclosed
US-5380899-A Process for the production of cyclic amidine LION AKZO CO., LTD. (JP) 1995-01-10 US disclosed
EP-0622357-A1 Process for the production of cyclic amidine LION AKZO COMPANY LIMITED (JP) 1994-11-02 EP disclosed
US-5030629-A Transdermal Administration Of Cardiovascular Agents THERAPEUTIC PATCH RESEARCH N.V. 1991-07-09 US disclosed
US-4876249-A TOPICAL; TRANSDERMAL, SYSTEMIC; FLUOCINOLINE ACETONIDE AND IMIDAZOLINE OR OXAZOLINE PENETRATION ENHANCER MIXTURE; THERAPEUTIC DRUGS THERAPEUTIC PATCH RESEARCH N.V. 1989-10-24 US disclosed
EP-0296199-A1 HETEROCYCLIC COMPOUNDS FOR TRANSDERMAL USE RAJADHYAKSHA, Vithal J. (US) 1988-12-28 EP disclosed
WO-1988004938-A1 HETEROCYCLIC COMPOUNDS FOR TRANSDERMAL USE RAJADHYAKSHA VITHAL J (US) 1988-07-14 WO disclosed
US-4185098-A (COCO-AMINO)ALKYL PHOSPHONATE INNER SALT AND N,N-DIMETHYL-N-(3-LAUROYLAMIDOPROPYL)AMINE HOECHST AKTIENGESELLSCHAFT (DE) 1980-01-22 US disclosed