Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8459500 | 0.82 | KDM4E (0.36) | KDM4EALDH1A1MAPTAOC3BRD4 | |
| Hydrochloric Acid SCHEMBL8462938 | 0.81 | KDM4E (0.35) | KDM4EALDH1A1MAPTAOC3BRD4 | |
| Hydrochloric Acid SCHEMBL8462900 | 0.78 | KDM4E (0.33) | KDM4EALDH1A1MAPTAOC3BRD4 | |
| Hydrochloric Acid SCHEMBL8459718 | 0.78 | PDGFRB (0.33) | KDM4EALDH1A1MAPTAOC3BRD4 | |
| Hydrochloric Acid SCHEMBL9009997 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL7595580 | 0.72 | — | — | |
| SCHEMBL4576627 | 0.68 | — | — | |
| Hydrochloric Acid SCHEMBL8461404 | 0.67 | AOC3 (0.47) | KDM4EALDH1A1MAPTAOC3BRD4 | |
| Hydrochloric Acid SCHEMBL9009970 | 0.65 | AOC3 (0.35) | KDM4EALDH1A1MAPTAOC3BRD4 | |
| Hydrochloric Acid SCHEMBL9010292 | 0.65 | LOXL2 (0.33) | KDM4EALDH1A1MAPTAOC3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741145-A1 | Olefin polymerization catalyst and process for producing polyolefin using the same | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1996-11-06 | — | — | EP | disclosed |