Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.66 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | F7 | P08709 | 1/20 | 0.53 |
| ▸ | F3 | P13726 | 1/20 | 0.53 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.53 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.53 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.50 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2259119 | 0.98 | HDAC1 (0.64) | HDAC1HDAC8PLOD2CYP3A4F7 | |
| SCHEMBL9763975 | 0.98 | HDAC1 (0.68) | HDAC1HDAC8PLOD2CYP3A4F7 | |
| Hydrochloric Acid SCHEMBL2259124 | 0.98 | HDAC1 (0.64) | HDAC1HDAC8PLOD2CYP3A4F7 | |
| SCHEMBL29963697 | 0.95 | HDAC1 (0.63) | HDAC1HDAC8PLOD2CYP3A4F7 | |
| SCHEMBL17700981 | 0.95 | HDAC1 (0.63) | HDAC1HDAC8PLOD2CYP3A4F7 | |
| Hydrochloric Acid SCHEMBL31026319 | 0.93 | HDAC1 (0.61) | HDAC1HDAC8PLOD2CYP3A4F7 | |
| Hydrochloric Acid SCHEMBL9490379 | 0.93 | HDAC1 (0.61) | HDAC1HDAC8PLOD2CYP3A4F7 | |
| SCHEMBL21133737 | 0.90 | PLOD2 (0.62) | HDAC1HDAC8PLOD2F7F3 | |
| SCHEMBL8545882 | 0.85 | HDAC1 (0.68) | HDAC1HDAC8PLOD2F7F3 | |
| SCHEMBL28975710 | 0.85 | HDAC1 (0.63) | HDAC1HDAC8PLOD2F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260088-A | Process for the preparation of nicotine and intermediates therefor | 武汉中有药业有限公司 | 2022-11-01 | — | — | CN | claimed |
| JP-8104674-A | — | — | None | — | — | JP | disclosed |
| CN-107406411-A | Process for the preparation of (R, S) -nicotine | 下代实验室有限责任公司 | 2017-11-28 | — | — | CN | disclosed |
| US-20170152443-A1 | LIQUID CRYSTAL ALIGNMENT AGENT, LIQUID CRYSTAL ALIGNMENT FILM, AND LIQUID CRYSTAL DISPLAY ELEMENT | CHI MEI CORPORATION (TW) | 2017-06-01 | — | — | US | disclosed |
| US-20170152443-A1 | LIQUID CRYSTAL ALIGNMENT AGENT, LIQUID CRYSTAL ALIGNMENT FILM, AND LIQUID CRYSTAL DISPLAY ELEMENT | CHI MEI CORPORATION (TW) | 2017-06-01 | — | — | US | disclosed |
| US-8008499-B2 | Anabaseine derivatives, pharmaceutical compositions and methods of use thereof | CORNERSTONE THERAPEUTICS, INC. (US) | 2011-08-30 | — | — | US | disclosed |
| US-20100311773-A1 | NOVEL ANABASEINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | Cornerstone Therapeutic, Inc. (US) | 2010-12-09 | — | — | US | disclosed |
| US-7662965-B2 | 3-(3-(2,5-dichlorophenyl)furan-2-yl)methylene)-3,4,5,6-tetrahydropyridin-2-yl)pyridine; antiinflammatory agent for inhibiting cytokine release from mammalian cells; treating CNS disorders; agonists of nicotinic acetylcholine receptors | CORNERSTONE THERAPEUTICS, INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-20070232651-A1 | Novel anabaseine derivatives, pharmaceutical compositions and methods of use thereof | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH | 2007-10-04 | — | — | US | disclosed |
| JP-H08104674-A | PRODUCTION OF PYRIDINE DERIVATIVE | TAIHO YAKUHIN KOGYO KK | 1996-04-23 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232651-A1 | Novel anabaseine derivatives, pharmaceutical compositions and methods of use thereof | CHRNA7, CHRNA10, CHRNA5 | HDAC1 889/4885HDAC8 512/4885PLOD2 4210/4885 |
| US-20100311773-A1 | NOVEL ANABASEINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | CHRNA7, CHRNA10, CHRNA5 | HDAC1 889/4885HDAC8 512/4885PLOD2 4210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.