Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 4/20 | 0.38 |
| ▸ | MC4R | P32245 | 2/20 | 0.38 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | MC5R | P33032 | 1/20 | 0.38 |
| ▸ | MC3R | P41968 | 1/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL27444819 | 0.89 | MEN1 (0.46) | GHSRKDM4EMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL27369426 | 0.87 | MEN1 (0.43) | GHSRKDM4EMEN1LMNAMPO | |
| Tryptophan SCHEMBL9010812 | 0.87 | MEN1 (0.43) | GHSRKDM4EMEN1LMNAMPO | |
| Lysine SCHEMBL9280396 | 0.85 | MEN1 (0.45) | GHSRKDM4EMEN1LMNAMPO | |
| SCHEMBL2638017 | 0.84 | KDM4E (0.48) | GHSRKDM4EMEN1LMNAMPO | |
| Phenylalanine SCHEMBL6437301 | 0.83 | GHSR (0.39) | GHSRMEN1KMT2ATLR2 | |
| Dl-Tryptophan SCHEMBL28632232 | 0.82 | KDM4E (0.53) | GHSRKDM4EMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL27344693 | 0.82 | MEN1 (0.48) | GHSRKDM4EMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL27642185 | 0.81 | MEN1 (0.43) | GHSRKDM4EMEN1LMNAMPO | |
| Arginine SCHEMBL17165033 | 0.81 | IL23R (0.40) | GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559142-A | NUTRIENTS | JAROWSKI CHARLES I (US) | 1996-09-24 | — | — | US | disclosed |