Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CTSC | P53634 | 2/20 | 0.43 |
| ▸ | MC4R | P32245 | 2/20 | 0.41 |
| ▸ | MC5R | P33032 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 11/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL27369426 | 1.00 | MEN1 (0.43) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL27444819 | 0.97 | MEN1 (0.46) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL27344693 | 0.95 | MEN1 (0.48) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL27642185 | 0.94 | MEN1 (0.43) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL28512725 | 0.92 | KDM4E (0.51) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL9280393 | 0.92 | MEN1 (0.52) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL9280401 | 0.92 | MEN1 (0.52) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL27677376 | 0.91 | TLR2 (0.37) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL27503845 | 0.91 | GHSR (0.39) | GHSR | |
| Dl-Tryptophan SCHEMBL28632232 | 0.90 | KDM4E (0.53) | MEN1KMT2AKDM4ELMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559142-A | NUTRIENTS | JAROWSKI CHARLES I (US) | 1996-09-24 | — | — | US | disclosed |