Erythromycin

SCHEMBL9011892

CCCCCCCCCCCCCCCCCCS(=O)(=O)O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H](O)[C@]1(C)O

nearest known ligand 0.87

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Erythromycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	ABCB11	O95342	2/20	0.87

▸	ABCC4	O15439	1/20	0.87

▸	CYP3A4	P08684	9/20	0.85

▸	KCNH2	Q12809	5/20	0.85

▸	ABCB1	P08183	2/20	0.85

▸	TSHR	P16473	2/20	0.85

▸	LMNA	P02545	2/20	0.85

▸	MLNR	O43193	2/20	0.85

▸	TDP1	Q9NUW8	1/20	0.85

▸	ALB	P02768	1/20	0.85

▸	CNR1	P21554	1/20	0.85

▸	HTR2A	P28223	1/20	0.85

▸	AOX1	Q06278	1/20	0.85

▸	CYP1B1	Q16678	1/20	0.85

▸	SLCO1B3	Q9NPD5	3/20	0.79

▸	SLCO1B1	Q9Y6L6	3/20	0.79

▸	MAPK1	P28482	2/20	0.79

▸	AR	P10275	1/20	0.79

▸	USP2	O75604	3/20	0.75

▸	MEN1	O00255	1/20	0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Erythromycin SCHEMBL9011755	1.00	ABCB11 (0.87)	ABCB11ABCC4CYP3A4KCNH2ABCB1
Erythromycin SCHEMBL9011887	1.00	ABCB11 (0.87)	ABCB11ABCC4CYP3A4KCNH2ABCB1
Erythromycin SCHEMBL28498097	1.00	ABCB11 (0.87)	ABCB11ABCC4CYP3A4KCNH2ABCB1
Erythromycin SCHEMBL9011752	1.00	ABCB11 (0.87)	ABCB11ABCC4CYP3A4KCNH2ABCB1
Erythromycin SCHEMBL284867	0.94	CYP3A4 (0.95)	ABCB11ABCC4CYP3A4KCNH2ABCB1
Erythromycin SCHEMBL284866	0.94	CYP3A4 (0.95)	ABCB11ABCC4CYP3A4KCNH2ABCB1
Erythromycin SCHEMBL11319270	0.93	ABCB11 (1.00)	ABCB11ABCC4CYP3A4KCNH2ABCB1
Erythromycin SCHEMBL7597008	0.93	ABCB11 (1.00)	ABCB11ABCC4CYP3A4KCNH2ABCB1
Erythromycin SCHEMBL7597003	0.93	ABCB11 (1.00)	ABCB11ABCC4CYP3A4KCNH2ABCB1
Erythromycin SCHEMBL11319266	0.93	ABCB11 (1.00)	ABCB11ABCC4CYP3A4KCNH2ABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5559098-A	Stable topical formulations with good active ingredient release characteristics, containing at least one lipophilized macrolide antibiotic	ROEHM PHARMA GMBH (DE)	1996-09-24	—	—	US	disclosed
US-5476843-A	Stable topical formulations with good active ingredient release characteristics, containing at least one lipophilized macrolide antibiotic	ROEHM PHARMA GMBH (DE)	1995-12-19	—	—	US	disclosed