Sugi Predict

Sugi Predict / Compounds / Erythromycin

Erythromycin

Erythromycin

SCHEMBL7597003

CCCCCCCCCCCCOS(=O)(=O)O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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The experimentally established mechanism targets of Erythromycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABCB11 O95342 2/20 1.00
▸ ABCC4 O15439 1/20 1.00
▸ CYP3A4 P08684 9/20 0.86
▸ SLCO1B3 Q9NPD5 3/20 0.86
▸ SLCO1B1 Q9Y6L6 3/20 0.86
▸ USP2 O75604 3/20 0.86
▸ MAPK1 P28482 2/20 0.86
▸ MEN1 O00255 1/20 0.86
▸ TP53 P04637 1/20 0.86
▸ MAPT P10636 1/20 0.86
▸ HPGD P15428 1/20 0.86
▸ ALOX12 P18054 1/20 0.86
▸ RECQL P46063 1/20 0.86
▸ BLM P54132 1/20 0.86
▸ KMT2A Q03164 1/20 0.86
▸ HSD17B10 Q99714 1/20 0.86
▸ KCNH2 Q12809 5/20 0.83
▸ ABCB1 P08183 2/20 0.83
▸ MLNR O43193 2/20 0.83
▸ TSHR P16473 2/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Erythromycin SCHEMBL7597008 1.00 ABCB11 (1.00) ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1
Erythromycin SCHEMBL11319266 1.00 ABCB11 (1.00) ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1
Erythromycin SCHEMBL11319270 1.00 ABCB11 (1.00) ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1
Erythromycin SCHEMBL3473986 0.97 ABCB11 (0.95) ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1
Clarithromycin SCHEMBL7596572 0.97 ABCB11 (0.94) ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1
Clarithromycin SCHEMBL7596567 0.97 ABCB11 (0.94) ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1
Erythromycin SCHEMBL9011752 0.93 ABCB11 (0.87) ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1
Erythromycin SCHEMBL9011887 0.93 ABCB11 (0.87) ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1
Erythromycin SCHEMBL28498097 0.93 ABCB11 (0.87) ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1
Erythromycin SCHEMBL9011892 0.93 ABCB11 (0.87) ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020037864-A1 2'-Propionate clarithromycin dodecyl sulfate and its preparation and pharmaceutical composition containing the same SHENG, JINHUO (CN) 2002-03-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020037864-A1 2'-Propionate clarithromycin dodecyl sulfate and its preparation and pharmaceutical composition containing the same DHCR7, HSD3B2, DECR2 ABCB11 82/4885ABCC4 691/4885CYP3A4 51/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.