SCHEMBL9012425

SCHEMBL9012425

CCCCCNNC(O)=S.NNC(O)=S.[KH]

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 10/20 0.36
HDAC1 Q13547 7/20 0.36
HDAC2 Q92769 6/20 0.36
ALOX15 P16050 1/20 0.35
ALDH1A1 P00352 1/20 0.34
TSHR P16473 1/20 0.34
HDAC11 Q96DB2 2/20 0.33
HDAC8 Q9BY41 2/20 0.33
HDAC6 Q9UBN7 1/20 0.33
EPHX1 P07099 5/20 0.32
NCOR2 Q9Y618 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9011360 0.98 HDAC3 (0.37) HDAC3HDAC1HDAC2ALOX15ALDH1A1
SCHEMBL7557328 0.80 HDAC1 (0.38) HDAC3HDAC1HDAC2ALOX15ALDH1A1
Heptane SCHEMBL10624295 0.79 TSHR (0.44) ALOX15ALDH1A1TSHRHDAC11EPHX1
SCHEMBL41078 0.75 ALDH1A1 (0.40) HDAC3HDAC1HDAC2ALDH1A1TSHR
SCHEMBL11226737 0.74 HDAC1 (0.41) HDAC3HDAC1HDAC2ALDH1A1TSHR
SCHEMBL28968579 0.74 HDAC1 (0.41) HDAC3HDAC1HDAC2ALDH1A1TSHR
SCHEMBL28415125 0.74 HDAC1 (0.41) HDAC3HDAC1HDAC2ALDH1A1TSHR
SCHEMBL28059471 0.74 HDAC1 (0.41) HDAC3HDAC1HDAC2ALDH1A1TSHR
SCHEMBL11033679 0.74 HDAC1 (0.41) HDAC3HDAC1HDAC2ALDH1A1TSHR
SCHEMBL6111687 0.74 HDAC1 (0.41) HDAC3HDAC1HDAC2ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5498720-A ANTIINFLAMMATORY AGENT USING 4H-1,2,4-TRIAZOL-3-THIOL DERIVATIVES LEE AN-RONG (TW) 1996-03-12 US disclosed