Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9012933 | 0.90 | PTGS2 (0.33) | PTGS2PTGS1EPAS1KMO | |
| SCHEMBL9012724 | 0.86 | EPAS1 (0.34) | EPAS1 | |
| SCHEMBL6401586 | 0.84 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL9013714 | 0.83 | PTGS2 (0.43) | PTGS2PTGS1EPAS1KMO | |
| SCHEMBL9012598 | 0.79 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL9013024 | 0.75 | NOTUM (0.40) | — | |
| SCHEMBL9013542 | 0.73 | PTGS2 (0.40) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9012951 | 0.73 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL5790164 | 0.71 | PTGS2 (0.41) | PTGS2PTGS1 | |
| SCHEMBL27587260 | 0.69 | PTGS2 (0.35) | PTGS2PTGS1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743938-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021817-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-08-17 | — | — | WO | disclosed |