Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | KMO | O15229 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9012776 | 0.90 | PTGS2 (0.39) | PTGS2PTGS1KMOEPAS1 | |
| SCHEMBL9012951 | 0.84 | PTGS2 (0.42) | PTGS2PTGS1FEN1 | |
| SCHEMBL9012724 | 0.83 | EPAS1 (0.34) | EPAS1 | |
| SCHEMBL9012598 | 0.81 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL9013714 | 0.80 | PTGS2 (0.43) | PTGS2PTGS1KMOEPAS1 | |
| SCHEMBL9013542 | 0.76 | PTGS2 (0.40) | PTGS2PTGS1KMT2AEPAS1 | |
| SCHEMBL9013024 | 0.75 | NOTUM (0.40) | MEN1KMT2A | |
| SCHEMBL6401586 | 0.73 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL9012694 | 0.71 | PTGS2 (0.44) | PTGS2PTGS1KMT2A | |
| SCHEMBL5790164 | 0.71 | PTGS2 (0.41) | PTGS2PTGS1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743938-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021817-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-08-17 | — | — | WO | disclosed |