Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 17/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 11/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.69 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.69 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.69 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.69 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.67 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.67 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.67 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809668 | 1.00 | CYP3A4 (0.69) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| SCHEMBL9047157 | 1.00 | CYP3A4 (0.69) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| SCHEMBL31366342 | 1.00 | CYP3A4 (0.69) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| SCHEMBL9044476 | 1.00 | CYP3A4 (0.69) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| SCHEMBL8809672 | 1.00 | CYP3A4 (0.69) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| SCHEMBL9048713 | 1.00 | CYP3A4 (0.69) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| SCHEMBL31512255 | 0.91 | CYP3A4 (0.57) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| SCHEMBL14408407 | 0.90 | CYP3A4 (0.71) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| SCHEMBL13106129 | 0.90 | CYP3A4 (0.71) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| SCHEMBL2912761 | 0.89 | CYP3A4 (0.70) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10626115-B2 | Fused pyrimidinone and triazinone derivatives containing bridged nitrogen, their process of preparation and their therapeutic uses as antifungal and/or antiparasitic agents | UNIVERSITE DE NANTES (FR) | 2020-04-21 | — | — | US | disclosed |
| US-20190002467-A1 | NOVEL FUSED PYRIMIDINONE AND TRIAZINONE DERIVATIVES CONTAINING BRIDGED NITROGEN, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC USES AS ANTIFUNGAL AND/OR ANTIPARASITIC AGENTS | UNIVERSITE DE NANTES (FR) | 2019-01-03 | — | — | US | disclosed |
| EP-0728752-A1 | Triazole compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-08-28 | — | — | EP | disclosed |
| US-5489606-A | FUNGICIDES, HUMAN, VETERNARY MEDICINE | SANKYO COMPANY, LIMITED (JP) | 1996-02-06 | — | — | US | disclosed |
| US-5405861-A | Fungicides | TAKEDA CHEMICAL INDUSTRIES, CO., LTD. (JP) | 1995-04-11 | — | — | US | disclosed |
| US-5393769-A | Thio-, sulfinyl- or sulfonyl-substituted | SANKYO COMPANY, LIMITED (JP) | 1995-02-28 | — | — | US | disclosed |
| US-5389663-A | Fungicides | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| US-5387599-A | Fungicide | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-07 | — | — | US | disclosed |
| US-5177094-A | TRIAZOLE COMPOUNDS HAVING ANTIFUNGAL PROPERTIES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| EP-0510700-A2 | Azole compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-10-28 | — | — | EP | disclosed |
| EP-0446877-A2 | Triazoles, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-09-18 | — | — | EP | disclosed |
| EP-0432717-A2 | Azole compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-06-19 | — | — | EP | disclosed |
| EP-0421210-A2 | Triazole compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-04-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10626115-B2 | Fused pyrimidinone and triazinone derivatives containing bridged nitrogen, their process of preparation and their therapeutic uses as antifungal and/or antiparasitic agents | DHFR, SAMHD1, TYMP | CYP3A4 209/4885CYP2C9 953/4885CYP2C19 309/4885 |
| US-20190002467-A1 | NOVEL FUSED PYRIMIDINONE AND TRIAZINONE DERIVATIVES CONTAINING BRIDGED NITROGEN, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC USES AS ANTIFUNGAL AND/OR ANTIPARASITIC AGENTS | SAMHD1, DHFR, TYMP | CYP3A4 273/4885CYP2C9 1342/4885CYP2C19 566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.