Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 14/20 | 0.47 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9012559 | 0.87 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL9012903 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL9012731 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1SCN9A | |
| SCHEMBL8386156 | 0.81 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL8388648 | 0.78 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL9012675 | 0.77 | SCN9A (0.43) | PTGS2PTGS1SCN9A | |
| SCHEMBL6548544 | 0.75 | F10 (0.52) | PTGS2PTGS1F10SCN9A | |
| SCHEMBL8384274 | 0.75 | PTGS2 (0.72) | PTGS2PTGS1 | |
| SCHEMBL8385282 | 0.74 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL8657376 | 0.73 | ABL1 (0.53) | PTGS2PTGS1F10SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743938-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021817-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-08-17 | — | — | WO | disclosed |