Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | FABP1 | P07148 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9012900 | 0.84 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL9012559 | 0.84 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL8384213 | 0.82 | PTGS2 (0.64) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL9012731 | 0.81 | PTGS2 (0.44) | PTGS2PTGS1CA2 | |
| SCHEMBL8385139 | 0.80 | PTGS2 (0.68) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8385441 | 0.77 | PTGS1 (0.67) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8385158 | 0.76 | PTGS2 (0.44) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8659145 | 0.75 | CA1 (0.53) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8384278 | 0.75 | PTGS2 (0.68) | PTGS2PTGS1 | |
| SCHEMBL9012675 | 0.74 | SCN9A (0.43) | PTGS2PTGS1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743938-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021817-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-08-17 | — | — | WO | disclosed |