Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119744 | 0.88 | PTGS2 (0.44) | PTGS2SMN1; SMN2 | |
| SCHEMBL9012598 | 0.86 | PTGS2 (0.43) | PTGS2PTGS1NR3C1 | |
| SCHEMBL9012728 | 0.85 | PTGS2 (0.46) | PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL5790164 | 0.85 | PTGS2 (0.41) | PTGS2PTGS1 | |
| SCHEMBL9012755 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL6402326 | 0.84 | PTGS2 (0.52) | PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL9012744 | 0.84 | NR1H2 (0.41) | PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL9012951 | 0.81 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL6401586 | 0.78 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL9117190 | 0.77 | PTGS2 (0.41) | PTGS2PTGS1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743938-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-27 | — | — | EP | claimed |
| WO-1995021817-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-08-17 | — | — | WO | claimed |
| EP-0743938-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021817-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-08-17 | — | — | WO | disclosed |