Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 3/20 | 0.35 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119744 | 0.84 | PTGS2 (0.44) | SMN1; SMN2LMNAHPGDHTTNPSR1 | |
| SCHEMBL9012907 | 0.84 | PTGS2 (0.50) | SMN1; SMN2PTGS2PTGS1 | |
| SCHEMBL9012633 | 0.82 | NOTUM (0.40) | NR1H2LMNAHTTNPSR1KMT2A | |
| SCHEMBL9012728 | 0.82 | PTGS2 (0.46) | NR1H2SMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL6402326 | 0.81 | PTGS2 (0.52) | SMN1; SMN2KMT2APTGS2PTGS1 | |
| SCHEMBL9012755 | 0.81 | PTGS2 (0.44) | SMN1; SMN2LMNAHPGDTP53PTGS2 | |
| SCHEMBL9012598 | 0.76 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL9013542 | 0.76 | PTGS2 (0.40) | NR1H2SMN1; SMN2LMNANPSR1KMT2A | |
| SCHEMBL9013714 | 0.75 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL9117190 | 0.74 | PTGS2 (0.41) | SMN1; SMN2TP53PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743938-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021817-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-08-17 | — | — | WO | disclosed |