Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | KARS1 | Q15046 | 6/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10086651 | 0.77 | KDM4E (0.53) | CHEK1CHEK2KARS1KDM4ECCNT1 | |
| SCHEMBL901730 | 0.76 | GRM2 (0.42) | MAPTABL1KDM4ECCNT1 | |
| SCHEMBL1367538 | 0.76 | JAK2 (0.64) | KARS1SYKEGFR | |
| SCHEMBL1367542 | 0.76 | JAK2 (0.64) | KARS1SYKEGFR | |
| SCHEMBL901823 | 0.75 | KARS1 (0.70) | KARS1PRKD1 | |
| SCHEMBL902088 | 0.73 | KARS1 (0.56) | CHEK1CHEK2KARS1SYKPRKD1 | |
| SCHEMBL10269158 | 0.69 | KARS1 (0.46) | CHEK1CHEK2KARS1MAPTADORA2A | |
| SCHEMBL901245 | 0.68 | KARS1 (0.52) | CHEK1CHEK2KARS1PRKD1 | |
| SCHEMBL10086672 | 0.68 | KDM4E (0.49) | CHEK1CHEK2KARS1KDM4E | |
| SCHEMBL901297 | 0.68 | KMT2A (0.44) | CHEK1KARS1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |