Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901328 | 0.86 | RAB9A (0.43) | KMT2AJAK2JAK1TYK2KDM4E | |
| SCHEMBL902713 | 0.81 | CHEK1 (0.39) | KMT2AJAK2JAK1TYK2KDM4E | |
| SCHEMBL10269158 | 0.76 | KARS1 (0.46) | KMT2AJAK2JAK1TYK2KDM4E | |
| SCHEMBL12469369 | 0.76 | SMN1; SMN2 (0.40) | KMT2AJAK2JAK1TYK2KDM4E | |
| SCHEMBL902023 | 0.74 | KDM4E (0.44) | KMT2AJAK2JAK1TYK2KDM4E | |
| SCHEMBL902723 | 0.73 | POLB (0.44) | KMT2AJAK2JAK1TYK2KDM4E | |
| SCHEMBL10086673 | 0.73 | ALDH1A1 (0.61) | KMT2AKDM4EMEN1 | |
| SCHEMBL5586094 | 0.72 | HCAR3 (0.44) | KDM4ENAPRTHCAR2MAPK1SMN1; SMN2 | |
| SCHEMBL476639 | 0.72 | ALDH1A1 (0.43) | KDM4EPOLBRAB9AMAPTNAPRT | |
| SCHEMBL1367155 | 0.71 | JAK2 (0.63) | KMT2AJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |