Tetrahydrofuran

Tetrahydrofuran

SCHEMBL9013725

C1CCOC1.O=C1OCCCCOC(=O)c2ccc1cc2

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.38
CA1 P00915 1/20 0.37
CA9 Q16790 1/20 0.37
SMN1; SMN2 Q16637 3/20 0.36
LMNA P02545 2/20 0.36
CRHBP P24387 2/20 0.36
CRHR2 Q13324 2/20 0.36
HTT P42858 1/20 0.36
NAMPT P43490 1/20 0.34
FAAH O00519 1/20 0.32
MGLL Q99685 1/20 0.32
NCOA3 Q9Y6Q9 1/20 0.32
CLK1 P49759 2/20 0.32
DYRK1A Q13627 2/20 0.32
DYRK1B Q9Y463 2/20 0.32
GAA P10253 2/20 0.32
KMT2A Q03164 2/20 0.32
MEN1 O00255 1/20 0.32
POLB P06746 1/20 0.32
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27671810 0.96 LMNA (0.43) ALDH1A1CA1CA9SMN1; SMN2LMNA
Tetrahydrofuran SCHEMBL28823175 0.95 SMN1; SMN2 (0.41) ALDH1A1CA1CA9SMN1; SMN2LMNA
SCHEMBL27681569 0.93 CA1 (0.39) ALDH1A1CA1CA9SMN1; SMN2LMNA
Oxirane SCHEMBL1696566 0.93 CA1 (0.39) ALDH1A1CA1CA9SMN1; SMN2LMNA
SCHEMBL36010 0.93 CA1 (0.42) ALDH1A1CA1CA9LMNANAMPT
SCHEMBL3873588 0.93 CA1 (0.42) ALDH1A1CA1CA9LMNANAMPT
SCHEMBL28713686 0.93 CA1 (0.42) ALDH1A1CA1CA9LMNANAMPT
Pharacine SCHEMBL3876076 0.93 CA1 (0.42) ALDH1A1CA1CA9LMNANAMPT
SCHEMBL28704246 0.93 CA1 (0.42) ALDH1A1CA1CA9LMNANAMPT
SCHEMBL597282 0.90 CA1 (0.40) ALDH1A1CA1CA9LMNANAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0602088-B1 ELECTRICAL CONNECTOR RAYCHEM SA NV (FR) 1996-12-04 EP disclosed
US-5418331-A Electrical connector RAYCHEM SA (FR) 1995-05-23 US disclosed
EP-0602088-A1 ELECTRICAL CONNECTOR. RAYCHEM SA NV (FR) 1994-06-22 EP disclosed
EP-0351982-B1 ELECTRICAL TERMINAL RAYCHEM PONTOISE S.A. (FR) 1993-10-06 EP disclosed
WO-1993005546-A1 ELECTRICAL CONNECTOR RAYCHEM S.A. (FR) 1993-03-18 WO disclosed
EP-0366700-B1 ELECTRICAL WIRE RAYCHEM LIMITED (GB) 1993-01-27 EP disclosed
US-5118313-A ELECTRICAL TERMINAL RAYCHEM SA (FR) 1992-06-02 US disclosed
EP-0366700-A1 ELECTRICAL WIRE. RAYCHEM LTD (GB) 1990-05-09 EP disclosed
EP-0351982-A1 Electrical terminal RAYCHEM PONTOISE S.A. (FR) 1990-01-24 EP disclosed
WO-1989000761-A1 ELECTRICAL WIRE RAYCHEM LIMITED (GB) 1989-01-26 WO disclosed