Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.75 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704874 | 0.94 | KARS1 (0.66) | KARS1TBK1GPR119SYKMEN1 | |
| SCHEMBL902626 | 0.93 | KARS1 (0.73) | KARS1TBK1GPR119SYKDYRK1A | |
| SCHEMBL1704251 | 0.91 | KARS1 (0.73) | KARS1TBK1GPR119SYKDYRK1A | |
| SCHEMBL1705003 | 0.90 | KARS1 (0.65) | KARS1TBK1GPR119SYKDYRK1A | |
| SCHEMBL1705312 | 0.90 | KARS1 (0.73) | KARS1TBK1GPR119SYKABL1 | |
| SCHEMBL902673 | 0.90 | KARS1 (0.65) | KARS1TBK1GPR119SYKABL1 | |
| SCHEMBL1704942 | 0.90 | KARS1 (0.64) | KARS1TBK1GPR119SYKWNT3A | |
| SCHEMBL901379 | 0.90 | KARS1 (0.64) | KARS1TBK1GPR119SYKDYRK1A | |
| SCHEMBL1704600 | 0.89 | KARS1 (0.73) | KARS1TBK1GPR119SYKDYRK1A | |
| SCHEMBL1704921 | 0.89 | KARS1 (0.63) | KARS1TBK1GPR119SYKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |