Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9013895 | 0.84 | KMT2A (0.38) | HRH3KMT2AMEN1RAB9AMAPT | |
| SCHEMBL9253235 | 0.79 | CCR3 (0.43) | CCR3KMT2AMEN1LMNAKDM4E | |
| SCHEMBL9014066 | 0.79 | CYP4F2 (0.49) | HRH3HRH1CCR3KMT2AKDM4E | |
| SCHEMBL9013798 | 0.78 | FFAR4 (0.44) | HRH3HRH1CCR3ACACB | |
| SCHEMBL9556943 | 0.77 | KDM4E (0.40) | HRH3KDM4EALDH1A1 | |
| SCHEMBL9013888 | 0.76 | FFAR4 (0.42) | HRH3RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL23465732 | 0.74 | GPR119 (0.63) | HRH3ALDH1A1 | |
| SCHEMBL9014050 | 0.73 | NAMPT (0.41) | HRH3CCR3 | |
| SCHEMBL9249677 | 0.73 | HSD17B3 (0.42) | KMT2AMEN1RAB9AMAPTLMNA | |
| Fumaric Acid SCHEMBL9013968 | 0.73 | HRH1 (0.53) | HRH3HRH1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580883-A | INHIBITING DEGENERATION AND NECROCYTOSIS OF CEREBRAL NERVE CELLS CAUSED BY OXIDATIVE STRESS INDUCING GLUTAMIC ACID IN MAMMALS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-03 | — | — | US | disclosed |
| EP-0449195-B1 | Aminobenzene compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-05-08 | — | — | EP | disclosed |
| EP-0449195-A2 | Aminobenzene compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-10-02 | — | — | EP | disclosed |