Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 11/20 | 0.87 |
| ▸ | FLT4 | P35916 | 11/20 | 0.87 |
| ▸ | KDR | P35968 | 11/20 | 0.87 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.79 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.69 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.69 |
| ▸ | EGFR | P00533 | 2/20 | 0.64 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | WDR5 | P61964 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287948 | 1.00 | FLT1 (0.87) | FLT1FLT4KDRL3MBTL1PTGS1 | |
| SCHEMBL10989349 | 0.93 | FLT1 (1.00) | FLT1FLT4KDRL3MBTL1PTGS1 | |
| SCHEMBL9176247 | 0.88 | FLT1 (1.00) | FLT1FLT4KDRL3MBTL1PTGS1 | |
| SCHEMBL8424044 | 0.86 | FLT1 (0.73) | FLT1FLT4KDRL3MBTL1PTGS1 | |
| SCHEMBL24224258 | 0.85 | FLT1 (0.84) | FLT1FLT4KDRL3MBTL1PTGS1 | |
| SCHEMBL9176789 | 0.85 | FLT1 (0.84) | FLT1FLT4KDRL3MBTL1PTGS1 | |
| SCHEMBL789891 | 0.85 | FLT1 (0.84) | FLT1FLT4KDRL3MBTL1PTGS1 | |
| SCHEMBL7278965 | 0.84 | P4HTM (0.65) | FLT1FLT4KDRL3MBTL1PTGS1 | |
| SCHEMBL7209929 | 0.83 | FLT1 (0.79) | FLT1FLT4KDRL3MBTL1PTGS1 | |
| SCHEMBL24224269 | 0.83 | FLT1 (0.79) | FLT1FLT4KDRL3MBTL1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0585155-B1 | Trifluoromethylketone derivatives of peptides having HLE inhibiting activity, their preparation and pharmaceutical composition | ADIR (FR) | 1996-12-11 | — | — | EP | disclosed |
| US-5565429-A | HUMAN LEUCOCYTE ELASTASE INHIBITORS; EMPHYSEMA; ANTIARTHRITIC AGENTS; RHEUMATIC DISEASES | ADIR ET COMPAGNIE (FR) | 1996-10-15 | — | — | US | disclosed |
| EP-0585155-A1 | Trifluoromethylketone derivatives of peptides having HLE inhibiting activity, their preparation and pharmaceutical composition | ADIR ET COMPAGNIE (FR) | 1994-03-02 | — | — | EP | disclosed |