Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.65 |
| ▸ | FLT1 | P17948 | 2/20 | 0.65 |
| ▸ | FLT4 | P35916 | 2/20 | 0.65 |
| ▸ | KDR | P35968 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.63 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.59 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.59 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.59 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8424044 | 0.95 | FLT1 (0.73) | P4HTMFLT1FLT4KDRMEN1 | |
| SCHEMBL5931288 | 0.94 | FLT1 (0.71) | P4HTMFLT1FLT4KDRMEN1 | |
| SCHEMBL174010 | 0.90 | FLT1 (0.77) | P4HTMFLT1FLT4KDRMEN1 | |
| SCHEMBL29011132 | 0.89 | FLT1 (0.74) | P4HTMFLT1FLT4KDRMEN1 | |
| Potassium SCHEMBL30358590 | 0.89 | FLT1 (0.74) | P4HTMFLT1FLT4KDRMEN1 | |
| SCHEMBL31331608 | 0.87 | BCL2L1 (0.75) | P4HTMFLT1FLT4KDRMEN1 | |
| SCHEMBL24347999 | 0.86 | PTGS2 (0.67) | P4HTMFLT1FLT4KDRMEN1 | |
| SCHEMBL12489988 | 0.86 | MEN1 (0.66) | P4HTMFLT1FLT4KDRMEN1 | |
| SCHEMBL8825440 | 0.86 | FLT1 (0.61) | P4HTMFLT1FLT4KDRMEN1 | |
| SCHEMBL8660071 | 0.86 | MEN1 (0.87) | P4HTMFLT1FLT4KDRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291234-B1 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC (US) | 1994-03-23 | — | — | EP | disclosed |
| EP-0272671-B1 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD (CH) | 1994-03-16 | — | — | EP | disclosed |
| US-5164371-A | HETEROCYCLIC KETONES | ICI AMERICAS INC. (US) | 1992-11-17 | — | — | US | disclosed |
| US-5158936-A | Treating or prevention of tissue damage, inflammation, bone resporpption and muscular dystrophy | SYNTEX (U.S.A.) INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5055451-A | Prevent tissue damage | SYNTEX INC. (US) | 1991-10-08 | — | — | US | disclosed |
| CN-1037519-A | HETEROCYCLIC KETONES | ICI AMERICA INC (US) | 1989-11-29 | — | — | CN | disclosed |
| US-4880780-A | RESPIRATORY SYSTEM DISORDERS | ICI AMERICAS INC. (US) | 1989-11-14 | — | — | US | disclosed |
| EP-0291234-A2 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC. (US) | 1988-11-17 | — | — | EP | disclosed |
| EP-0272671-A2 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD. (CH) | 1988-06-29 | — | — | EP | disclosed |