Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 3/20 | 0.73 |
| ▸ | FLT4 | P35916 | 3/20 | 0.73 |
| ▸ | KDR | P35968 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.61 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.54 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.54 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.54 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7278965 | 0.95 | P4HTM (0.65) | FLT1FLT4KDRMEN1LMNA | |
| SCHEMBL5931288 | 0.89 | FLT1 (0.71) | FLT1FLT4KDRMEN1LMNA | |
| SCHEMBL174010 | 0.89 | FLT1 (0.77) | FLT1FLT4KDRMEN1LMNA | |
| Potassium SCHEMBL30358590 | 0.87 | FLT1 (0.74) | FLT1FLT4KDRMEN1LMNA | |
| SCHEMBL29011132 | 0.87 | FLT1 (0.74) | FLT1FLT4KDRMEN1LMNA | |
| SCHEMBL3300299 | 0.86 | FLT1 (0.73) | FLT1FLT4KDRMEN1LMNA | |
| SCHEMBL9014174 | 0.86 | FLT1 (0.87) | FLT1FLT4KDRL3MBTL1BCL2L1 | |
| SCHEMBL9967798 | 0.86 | FLT1 (0.69) | FLT1FLT4KDRMEN1LMNA | |
| SCHEMBL376340 | 0.86 | MEN1 (0.73) | FLT1FLT4KDRMEN1LMNA | |
| SCHEMBL7287948 | 0.86 | FLT1 (0.87) | FLT1FLT4KDRL3MBTL1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5907068-A | TRIFLUOROMETHYLSUBSTITUTED COMPOUND INCLUDED IN PEPTIDES | ZENECA INC. (US) | 1999-05-25 | — | — | US | disclosed |
| US-5726158-A | INHIBITORS OF HUMAN LEUKOCYTE ELASTASE USEFUL IN TREATING TISSUE DEGENERATIVE DISEASES; TRIFLUOROMETHYL KETONE SUBSTITUTED DI-, TRI-, AND TETRA-PEPTIDE DERIVATIVES | ZENECA INC. (US) | 1998-03-10 | — | — | US | disclosed |
| US-5414132-A | Peptide intermediates | ZENECA INC. (US) | 1995-05-09 | — | — | US | disclosed |
| US-5194588-A | Inhibitors of human leukocyte elastase, di-, tri- and tetra-peptides | ICI AMERICAS INC. (US) | 1993-03-16 | — | — | US | disclosed |
| US-5055450-A | Di-, tri- and tetrapeptides as inhibitors of human leukocyte elastase | ICI AMERICAS INC. (US) | 1991-10-08 | — | — | US | disclosed |
| US-4910190-A | Containing a nitrogen containing heterocycle ring structure | ICI AMERICAS INC. (US) | 1990-03-20 | — | — | US | disclosed |