Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 13/20 | 0.68 |
| ▸ | BCR | P11274 | 12/20 | 0.68 |
| ▸ | PRKCA | P17252 | 8/20 | 0.68 |
| ▸ | SRC | P12931 | 7/20 | 0.68 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.68 |
| ▸ | EGFR | P00533 | 3/20 | 0.68 |
| ▸ | PRKACA | P17612 | 1/20 | 0.68 |
| ▸ | PRKACG | P22612 | 1/20 | 0.68 |
| ▸ | PRKACB | P22694 | 1/20 | 0.68 |
| ▸ | AURKA | O14965 | 2/20 | 0.63 |
| ▸ | CLK1 | P49759 | 1/20 | 0.63 |
| ▸ | CLK2 | P49760 | 1/20 | 0.63 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.63 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.63 |
| ▸ | KIF11 | P52732 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | PRKCG | P05129 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4901590 | 0.88 | ABL1 (0.67) | ABL1BCRPRKCASRCAURKA | |
| SCHEMBL27116019 | 0.86 | CLK1 (0.59) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL27119203 | 0.85 | AURKA (0.63) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL27116136 | 0.85 | CLK1 (0.62) | ABL1BCRAURKACLK1CLK2 | |
| SCHEMBL25336406 | 0.84 | CAMK2D (0.69) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL27115596 | 0.84 | SYK (0.65) | SRCAURKACLK1CLK2DYRK1A | |
| SCHEMBL30554563 | 0.84 | CAMK2D (0.69) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL13887208 | 0.84 | KIF11 (0.63) | ABL1BCRPRKCAPRKCDAURKA | |
| SCHEMBL3514414 | 0.84 | AURKA (0.64) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL7461678 | 0.84 | ABL1 (0.73) | ABL1BCRPRKCASRCPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516775-A | TO INHIBIT PROTEIN KINASE C | CIBA-GEIGY CORPORATION (US) | 1996-05-14 | — | — | US | claimed |
| US-5516775-A | TO INHIBIT PROTEIN KINASE C | CIBA-GEIGY CORPORATION (US) | 1996-05-14 | — | — | US | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | disclosed |