Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.81 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281276 | 0.90 | REN (1.00) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9014804 | 0.90 | REN (1.00) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7280464 | 0.88 | REN (0.80) | REN | |
| SCHEMBL9014876 | 0.86 | REN (0.64) | REN | |
| SCHEMBL9632624 | 0.86 | REN (0.64) | REN | |
| SCHEMBL9014890 | 0.86 | REN (0.64) | REN | |
| SCHEMBL7280113 | 0.86 | REN (0.64) | REN | |
| SCHEMBL7278484 | 0.85 | REN (0.81) | REN | |
| SCHEMBL7272808 | 0.82 | REN (0.58) | REN | |
| SCHEMBL9014850 | 0.82 | REN (0.58) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545838-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-08-13 | — | — | US | disclosed |
| US-5098924-A | Hypotensive agents and angiotensin II inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1992-03-24 | — | — | US | disclosed |