Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 2/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014867 | 1.00 | CHRNA1 (0.55) | CHRNA1CHRNA3CHRNA7ALDH1A1CHRNB2 | |
| SCHEMBL9069342 | 1.00 | CHRNA1 (0.55) | CHRNA1CHRNA3CHRNA7ALDH1A1CHRNB2 | |
| SCHEMBL9070393 | 0.98 | CHRNA1 (0.55) | CHRNA1CHRNA3CHRNA7ALDH1A1CHRNB2 | |
| SCHEMBL9070395 | 0.98 | CHRNA1 (0.55) | CHRNA1CHRNA3CHRNA7ALDH1A1CHRNB2 | |
| SCHEMBL9070406 | 0.83 | CHRNA1 (0.39) | CHRNA1CHRNA3CHRNA7ALDH1A1CHRNB2 | |
| SCHEMBL9070405 | 0.83 | CHRNA1 (0.39) | CHRNA1CHRNA3CHRNA7ALDH1A1CHRNB2 | |
| SCHEMBL10428365 | 0.82 | ALDH1A1 (0.57) | CHRNA1CHRNA3CHRNA7ALDH1A1CHRNB2 | |
| SCHEMBL5197319 | 0.82 | ALDH1A1 (0.57) | CHRNA1CHRNA3CHRNA7ALDH1A1CHRNB2 | |
| SCHEMBL8113019 | 0.80 | CHRNA1 (0.66) | CHRNA1CHRNA3CHRNA7ALDH1A1CHRNB2 | |
| SCHEMBL676764 | 0.80 | CHRNA1 (0.66) | CHRNA1CHRNA3CHRNA7ALDH1A1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5547965-A | TREATMENT AND PREVENTION OF SENILE, PRESENILE, AND ALZHEIMER'S DEMENTIA, AND DEPRESSION | BAYER AKTIENGESELLSCHAFT (DE) | 1996-08-20 | — | — | US | claimed |
| EP-0679397-A2 | Use of substituted amines for the treatment of cerebral insufficiencies | BAYER AG (DE) | 1995-11-02 | — | — | EP | claimed |
| US-5547965-A | TREATMENT AND PREVENTION OF SENILE, PRESENILE, AND ALZHEIMER'S DEMENTIA, AND DEPRESSION | BAYER AKTIENGESELLSCHAFT (DE) | 1996-08-20 | — | — | US | disclosed |
| EP-0679397-A2 | Use of substituted amines for the treatment of cerebral insufficiencies | BAYER AG (DE) | 1995-11-02 | — | — | EP | disclosed |