Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046244 | 0.85 | HTR2A (0.48) | HTR2AMAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL6618364 | 0.81 | HTR2A (0.53) | HTR2AMAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL6619002 | 0.80 | HTR2A (0.50) | HTR2ATDP1KMT2ASRD5A2ALDH1A1 | |
| SCHEMBL27472077 | 0.79 | HTR2A (0.51) | HTR2AMAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL6315078 | 0.78 | HTR2A (0.50) | HTR2AMAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL2072518 | 0.78 | SLC6A4 (0.59) | HTR2AMAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL28374945 | 0.77 | HTR2A (0.63) | HTR2AMAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL10971276 | 0.77 | HTR2A (0.49) | HTR2AMAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL27682948 | 0.77 | HTR2A (0.51) | HTR2AMAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL9206148 | 0.76 | HTR2A (0.66) | HTR2AMAPTMAPK1MITFLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5569661-A | Process for the production of b-carbolines | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-10-29 | — | — | US | disclosed |
| EP-0670837-B1 | METHOD OF PREPARING BETA-CARBOLINES | SCHERING AG (DE) | 1996-10-16 | — | — | EP | disclosed |
| EP-0670837-A1 | METHOD OF PREPARING -g(b)-CARBOLINES. | SCHERING AG (DE) | 1995-09-13 | — | — | EP | disclosed |
| US-5401854-A | Process for the production of indole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-03-28 | — | — | US | disclosed |
| WO-1994012498-A1 | METHOD OF PREPARING β-CARBOLINES | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-06-09 | — | — | WO | disclosed |