Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9015352 | 1.00 | KDM4E (0.49) | KDM4ECA1CA2NFKB1CA4 | |
| SCHEMBL9254890 | 0.85 | PRKDC (0.39) | KDM4ECA1CA2CYP19A1HTT | |
| SCHEMBL9254892 | 0.85 | PRKDC (0.39) | KDM4ECA1CA2CYP19A1HTT | |
| SCHEMBL9015376 | 0.73 | KDM4E (0.60) | KDM4ECA1CA2NFKB1CA4 | |
| SCHEMBL9015375 | 0.73 | KDM4E (0.60) | KDM4ECA1CA2NFKB1CA4 | |
| SCHEMBL11719449 | 0.67 | PSMB5 (0.54) | KDM4EMAPT | |
| SCHEMBL21218866 | 0.67 | KDM4E (0.48) | KDM4ECA1CA2NFKB1CA4 | |
| SCHEMBL9297750 | 0.67 | NFKB1 (0.67) | KDM4ECA1CA2NFKB1CA4 | |
| SCHEMBL10474273 | 0.66 | KDM4E (0.68) | KDM4ECA1CA2NFKB1CA4 | |
| SCHEMBL10474271 | 0.66 | KDM4E (0.68) | KDM4ECA1CA2NFKB1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0648741-B1 | 1,2,3,4-Tetrahydronaphthalene, chroman and thiochroman derivatives as antithrombotic agents | ADIR (FR) | 1996-12-18 | — | — | EP | disclosed |
| EP-0648741-A1 | 1,2,3,4-Tetrahydronaphthalene, chroman and thiochroman derivatives as antithrombotic agents | ADIR ET COMPAGNIE (FR) | 1995-04-19 | — | — | EP | disclosed |