Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 3/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | GCGR | P47871 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | FRK | P42685 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18039087 | 0.78 | ADORA2B (0.58) | ADORA2BADORA2AMAPK14MAPK13MAPK12 | |
| SCHEMBL18039107 | 0.78 | ADORA2B (0.68) | ADORA2BADORA2AMAPK14MAPK13MAPK12 | |
| SCHEMBL10981717 | 0.77 | ALOX5 (0.42) | ADORA2BMAPK14ALOX5MAPTCSNK1D | |
| SCHEMBL18652678 | 0.76 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11MAPK10 | |
| SCHEMBL19837870 | 0.76 | ADORA2B (0.49) | ADORA2BADORA2AMAPK14MAPK13MAPK12 | |
| SCHEMBL1225544 | 0.76 | ADORA2B (0.49) | ADORA2BADORA2AMAPK14MAPK13MAPK12 | |
| SCHEMBL30969923 | 0.74 | EGLN2 (0.40) | ADORA2AMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL18076787 | 0.74 | EGLN2 (0.40) | ADORA2AMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL31517665 | 0.71 | MAPK14 (0.53) | ADORA2BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL19376952 | 0.71 | ADORA2A (0.53) | ADORA2BADORA2AMAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |
| US-4497816-A | 7-(4-Pyridyl)-1,8-naphthyridine derivatives and their antibacterial compositions | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1985-02-05 | — | — | US | disclosed |