SCHEMBL9016261

SCHEMBL9016261

FC(F)(F)c1ccc(Cl)cc1.FC(F)(F)c1ccccc1Cl

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 3/20 0.46
ALDH1A1 P00352 1/20 0.44
TSHR P16473 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP3A5 P20815 1/20 0.44
KIF11 P52732 1/20 0.43
KCNN4 O15554 1/20 0.42
NR1H2 P55055 2/20 0.42
NR1H3 Q13133 2/20 0.42
GAA P10253 1/20 0.40
TP53 P04637 1/20 0.40
MAPT P10636 1/20 0.40
KCNJ5 P48544 1/20 0.40
KCNJ3 P48549 1/20 0.40
GRIN2B Q13224 1/20 0.40
HSD11B1 P28845 2/20 0.39
KMT2A Q03164 1/20 0.39
AHR P35869 1/20 0.39
KDM4E B2RXH2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL117692 0.85 KCNN4 (0.48) CYP19A1ALDH1A1TSHRKCNN4GAA
SCHEMBL5966718 0.85 KCNN4 (0.48) CYP19A1ALDH1A1TSHRKCNN4GAA
SCHEMBL29467226 0.85 KCNN4 (0.48) CYP19A1ALDH1A1TSHRKCNN4GAA
SCHEMBL29057192 0.83 KCNN4 (0.46) CYP19A1ALDH1A1TSHRKCNN4KCNJ5
Benzene SCHEMBL29136712 0.83 KCNN4 (0.52) CYP19A1ALDH1A1TSHRKCNN4KCNJ5
Ammonia Solution, Strong SCHEMBL15562823 0.83 KCNN4 (0.46) CYP19A1ALDH1A1TSHRKCNN4KCNJ5
SCHEMBL28034993 0.83 KCNN4 (0.46) CYP19A1ALDH1A1TSHRKCNN4KCNJ5
SCHEMBL5607381 0.83 KCNN4 (0.46) CYP19A1ALDH1A1TSHRKCNN4KCNJ5
SCHEMBL4463108 0.83 KCNN4 (0.46) CYP19A1ALDH1A1TSHRKCNN4KCNJ5
SCHEMBL6564279 0.82 ALDH1A1 (0.63) CYP19A1ALDH1A1TSHRKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0630394-B1 SOLVENT MIXTURES HAVING ENHANCED EVAPORATION OCCIDENTAL CHEM CO (US) 1996-12-27 EP claimed