Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triaziquone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 5/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.32 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.32 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triaziquone SCHEMBL8330857 | 0.86 | GRM8 (0.47) | DNMT1GRIK1GRIK2GRM1GRM2 | |
| Triaziquone SCHEMBL7913123 | 0.85 | DNMT1 (0.35) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL4745473 | 0.84 | SMN1; SMN2 (0.43) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL3191414 | 0.82 | DNMT1 (0.38) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL19976110 | 0.82 | DNMT1 (0.36) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL3505984 | 0.81 | DNMT1 (0.37) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL6243103 | 0.81 | DNMT1 (0.36) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL1892343 | 0.81 | DNMT1 (0.39) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL22346328 | 0.81 | DNMT1 (0.39) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL4299467 | 0.81 | DNMT1 (0.39) | DNMT1TP53MAPTSTAT3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5556748-A | Methods of sandwich hybridization for the quantitative analysis of oligonucleotides | XENOPORE CORPORATION (US) | 1996-09-17 | — | — | US | disclosed |
| EP-0605430-A1 | KIT FOR LIQUID PHASE QUANTITATIVE ANALYSIS OF OLIGONUCLEOTIDES AND METHOD OF USE THEREOF | XENOPORE CORPORATION (US) | 1994-07-13 | — | — | EP | disclosed |
| EP-0596915-A1 | DEVICE FOR OLIGONUCLEOTIDE ASSAY AND METHOD OF PREPARATION THEREOF | XENOPORE CORPORATION (US) | 1994-05-18 | — | — | EP | disclosed |
| WO-1993003181-A1 | DEVICE FOR OLIGONUCLEOTIDE ASSAY AND METHOD OF PREPARATION THEREOF | XENOPORE CORPORATION (US) | 1993-02-18 | — | — | WO | disclosed |
| WO-1993003182-A1 | KIT FOR LIQUID PHASE QUANTITATIVE ANALYSIS OF OLIGONUCLEOTIDES AND METHOD OF USE THEREOF | XENOPORE CORPORATION (US) | 1993-02-18 | — | — | WO | disclosed |