SCHEMBL9016341

SCHEMBL9016341

Cc1ccc(P(c2ccc(C)cc2)c2ccccc2-c2ccccc2P(c2ccc(C)cc2)c2ccc(C)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.38
ACHE P22303 2/20 0.38
TSHR P16473 1/20 0.38
ALOX12 P18054 1/20 0.38
TDP1 Q9NUW8 4/20 0.36
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
MAPT P10636 4/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
ALDH1A1 P00352 2/20 0.36
CYP2C9 P11712 2/20 0.36
CYP2C19 P33261 2/20 0.36
USP2 O75604 1/20 0.36
POLB P06746 1/20 0.36
NOD2 Q9HC29 1/20 0.36
CYP3A4 P08684 1/20 0.36
ELANE P08246 1/20 0.34
NPSR1 Q6W5P4 2/20 0.34
HKDC1 Q2TB90 1/20 0.34
DRD1 P21728 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6252132 0.88 ACHE (0.43) LMNAACHETSHRALOX12TDP1
SCHEMBL29669786 0.84 TDP1 (0.41) LMNAACHETSHRALOX12TDP1
SCHEMBL30477646 0.82 ACHE (0.36) LMNAACHETSHRALOX12TDP1
SCHEMBL1120987 0.80 CYP3A4 (0.58) TDP1MEN1KMT2ACYP3A4NPSR1
SCHEMBL28825736 0.79 MYC (0.35) MEN1KMT2ADRD1TOP1NPC1
SCHEMBL29635212 0.78 CYP3A4 (0.44) ACHETSHRTDP1ALDH1A1CYP2C19
SCHEMBL4000406 0.78 CYP3A4 (0.44) ACHETSHRTDP1ALDH1A1CYP2C19
SCHEMBL5680437 0.78 ACHE (0.35) LMNAACHETSHRALOX12TDP1
SCHEMBL16760866 0.78 TDP1 (0.44) LMNAACHETSHRALOX12TDP1
SCHEMBL1683360 0.78 ALDH1A1 (0.39) LMNAACHETSHRALOX12TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0683786-B1 PROCESS FOR THE PREPARATION OF LITHIUM DIARYLPHOSPHIDES AND ALKYLATED DERIVATIVES THEREOF EASTMAN CHEM CO (US) 1996-12-18 EP disclosed
EP-0683786-A1 PROCESS FOR THE PREPARATION OF LITHIUM DIARYLPHOSPHIDES AND ALKYLATED DERIVATIVES THEREOF. EASTMAN CHEM CO (US) 1995-11-29 EP disclosed
US-5354894-A Treating triarylphosphine with lithium and a primary or secondary amine EASTMAN CHEMICAL COMPANY (US) 1994-10-11 US disclosed
WO-1994018211-A1 PROCESS FOR THE PREPARATION OF LITHIUM DIARYLPHOSPHIDES AND ALKYLATED DERIVATIVES THEREOF EASTMAN CHEMICAL COMPANY (US) 1994-08-18 WO disclosed
US-5288912-A Hydrohalogenation of a triarylphosphine; alkylation; using lithium diarylphosphine as chemical intermediate EASTMAN KODAK COMPANY (US) 1994-02-22 US disclosed