Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29271879 | 0.94 | LMNA (0.39) | MEN1KMT2ALMNAPOLBALDH1A1 | |
| SCHEMBL7999549 | 0.85 | MEN1 (0.39) | MEN1KMT2ALMNAPOLBEPHX2 | |
| SCHEMBL10805179 | 0.83 | MEN1 (0.38) | MEN1KMT2ALMNAPOLBEPHX2 | |
| SCHEMBL5521474 | 0.83 | MEN1 (0.38) | MEN1KMT2ALMNAPOLBEPHX2 | |
| SCHEMBL6299545 | 0.83 | MEN1 (0.38) | MEN1KMT2ALMNAPOLBEPHX2 | |
| SCHEMBL8750705 | 0.82 | MGAM (0.38) | MEN1KMT2ALMNAPOLBEPHX2 | |
| SCHEMBL5679436 | 0.81 | LMNA (0.38) | MEN1KMT2ALMNAPOLBALDH1A1 | |
| SCHEMBL20357987 | 0.81 | CHRM2 (0.38) | MEN1KMT2ALMNAPOLBEPHX2 | |
| SCHEMBL3812571 | 0.81 | CHRM2 (0.38) | MEN1KMT2ALMNAPOLBEPHX2 | |
| SCHEMBL3981084 | 0.81 | MEN1 (0.38) | MEN1KMT2ALMNAPOLBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621931-A1 | TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION | Merck Sharp & Dohme Corp. (US) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012041014-A1 | TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |