Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | CCL2 | P13500 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7823998 | 0.76 | BRD4 (0.41) | BRD4CCL2CYP3A4MAOALMNA | |
| SCHEMBL9016934 | 0.74 | BRD4 (0.42) | BRD4CCL2CYP3A4MAOALMNA | |
| SCHEMBL28131615 | 0.74 | BRD4 (0.42) | BRD4CCL2CYP3A4MAOALMNA | |
| SCHEMBL7032000 | 0.74 | BRD4 (0.42) | BRD4CCL2CYP3A4MAOALMNA | |
| SCHEMBL28130908 | 0.74 | BRD4 (0.42) | BRD4CCL2CYP3A4MAOALMNA | |
| Hydrochloric Acid SCHEMBL10592962 | 0.74 | BRD4 (0.44) | BRD4CYP3A4CA2MAPT | |
| SCHEMBL8041045 | 0.72 | BRD4 (0.41) | BRD4CCL2CYP3A4MAOALMNA | |
| SCHEMBL7826476 | 0.70 | BRD4 (0.40) | BRD4CCL2CYP3A4MAOALMNA | |
| SCHEMBL8041103 | 0.66 | BRD4 (0.36) | BRD4CCL2CYP3A4CA2 | |
| SCHEMBL18287893 | 0.65 | CYP3A4 (0.50) | BRD4CCL2CYP3A4MAOALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5504232-A | Process for the preparation of an olefin polymer using specific metallocenes | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-04-02 | — | — | US | disclosed |