Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.61 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 6/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | PRKACA | P17612 | 1/20 | 0.60 |
| ▸ | LTK | P29376 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.60 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.60 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.60 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.60 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.60 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17598134 | 0.89 | EGFR (0.57) | TTBK1TTBK2EGFRABCG2DAPK3 | |
| SCHEMBL31747067 | 0.86 | KMT2A (0.57) | EGFRABCG2DAPK3MAP4K4ABL1 | |
| SCHEMBL2700855 | 0.86 | EGFR (0.64) | EGFRABCG2DAPK3MAP4K4ABL1 | |
| SCHEMBL5568076 | 0.86 | KMT2A (0.57) | EGFRABCG2DAPK3MAP4K4ABL1 | |
| SCHEMBL5568397 | 0.84 | EGFR (0.68) | EGFRABCG2DAPK3MAP4K4ABL1 | |
| SCHEMBL11092575 | 0.84 | EGFR (0.63) | TTBK1TTBK2EGFRERBB2DYRK1A | |
| SCHEMBL11091920 | 0.84 | TTBK1 (0.59) | TTBK1TTBK2EGFRAURKBMEN1 | |
| Hydrochloric Acid SCHEMBL11089555 | 0.83 | TTBK1 (0.58) | TTBK1TTBK2EGFRAURKBMEN1 | |
| Hydrochloric Acid SCHEMBL11088198 | 0.83 | EGFR (0.62) | TTBK1TTBK2EGFRERBB2DYRK1A | |
| SCHEMBL8976752 | 0.82 | EGFR (0.78) | EGFRABCG2DAPK3MAP4K4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520722-B1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LTD (GB) | 1996-12-27 | — | — | EP | disclosed |
| EP-0520722-A1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |