Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.31 |
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.30 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28927325 | 0.83 | LMNA (0.81) | LMNABLMPTPN1MEN1CYP3A4 | |
| Hydrochloric Acid SCHEMBL28927326 | 0.83 | LMNA (0.81) | LMNABLMPTPN1MEN1CYP3A4 | |
| SCHEMBL20928 | 0.83 | LMNA (0.93) | LMNABLMPTPN1MEN1CYP3A4 | |
| SCHEMBL29662067 | 0.83 | LMNA (0.93) | LMNABLMPTPN1MEN1CYP3A4 | |
| SCHEMBL8672325 | 0.83 | LMNA (0.93) | LMNABLMPTPN1MEN1CYP3A4 | |
| SCHEMBL538230 | 0.83 | LMNA (0.93) | LMNABLMPTPN1MEN1CYP3A4 | |
| SCHEMBL2985725 | 0.80 | LMNA (1.00) | LMNABLMPTPN1MEN1CYP3A4 | |
| SCHEMBL11601594 | 0.80 | LMNA (0.87) | LMNABLMPTPN1MEN1CYP3A4 | |
| Squalane SCHEMBL15449 | 0.80 | LMNA (1.00) | LMNABLMPTPN1MEN1CYP3A4 | |
| Squalane SCHEMBL4708649 | 0.80 | LMNA (1.00) | LMNABLMPTPN1MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0414106-B1 | Process for the preparation of terpenes | EISAI CO LTD (JP) | 1996-03-27 | — | — | EP | disclosed |
| US-5073659-A | Alkylation, Grignard reagent, zinc chloride catalyst and coppe r compound | EISAI CO., LTD. (JP) | 1991-12-17 | — | — | US | disclosed |
| CN-1049650-A | The terpenic preparation method | EISAI CO LTD (JP) | 1991-03-06 | — | — | CN | disclosed |
| EP-0414106-A2 | Process for the preparation of terpenes | Eisai Co., Ltd. (JP) | 1991-02-27 | — | — | EP | disclosed |