Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.49 |
| ▸ | CASP2 | P42575 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24096052 | 0.98 | TDP1 (0.58) | TDP1MAOAMAOBMEN1KMT2A | |
| SCHEMBL14723706 | 0.91 | TDP1 (0.66) | TDP1MAOAMAOBMEN1KMT2A | |
| SCHEMBL178408 | 0.88 | TDP1 (0.70) | TDP1MAOAMAOBMEN1KMT2A | |
| SCHEMBL3311637 | 0.87 | TDP1 (0.75) | TDP1MAOAMAOBMEN1KMT2A | |
| SCHEMBL25963881 | 0.86 | MAOA (0.61) | TDP1MAOAMAOBMEN1KMT2A | |
| SCHEMBL16436993 | 0.86 | TDP1 (0.73) | TDP1MAOAMAOBMEN1KMT2A | |
| SCHEMBL3365771 | 0.86 | TDP1 (0.73) | TDP1MAOAMAOBMEN1KMT2A | |
| SCHEMBL7106115 | 0.86 | TDP1 (0.73) | TDP1MAOAMAOBMEN1KMT2A | |
| SCHEMBL8737682 | 0.86 | TDP1 (0.73) | TDP1MAOAMAOBMEN1KMT2A | |
| SCHEMBL14877952 | 0.86 | TDP1 (0.73) | TDP1MAOAMAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746544-A1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995022524-A1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-24 | — | — | WO | disclosed |