Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 8/20 | 0.44 |
| ▸ | TUBB | P07437 | 8/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 8/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 8/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 8/20 | 0.44 |
| ▸ | TUBB6 | Q9BUF5 | 8/20 | 0.44 |
| ▸ | TUBB2B | Q9BVA1 | 8/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 8/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017486 | 0.83 | TUBB4A (0.41) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7694013 | 0.83 | AKR1C2 (0.46) | PPARG | |
| SCHEMBL7693001 | 0.81 | AKR1C2 (0.49) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7698410 | 0.77 | AKR1C2 (0.46) | — | |
| SCHEMBL7698626 | 0.73 | GAA (0.49) | — | |
| SCHEMBL24098774 | 0.73 | PPARG (0.61) | PPARG | |
| SCHEMBL30218292 | 0.73 | PPARG (0.61) | PPARG | |
| SCHEMBL8648925 | 0.72 | AKR1C2 (0.65) | PPARGTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6013487 | 0.72 | AKR1C2 (0.46) | — | |
| SCHEMBL7699710 | 0.72 | AKR1C2 (0.46) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746544-A1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995022524-A1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-24 | — | — | WO | disclosed |