Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.48 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27346 | 0.96 | ALDH1A1 (0.56) | ALDH1A1MAPK1TSHRTDP1ZDHHC20 | |
| Hydrochloric Acid SCHEMBL2804444 | 0.94 | ALDH1A1 (0.54) | ALDH1A1MAPK1TSHRTDP1ZDHHC20 | |
| Chloromethane SCHEMBL1099332 | 0.92 | ALDH1A1 (0.52) | ALDH1A1MAPK1TSHRTDP1ZDHHC20 | |
| Methacrylic Acid SCHEMBL28850506 | 0.89 | ALDH1A1 (0.50) | ALDH1A1MAPK1TSHRTDP1ZDHHC20 | |
| SCHEMBL27782054 | 0.89 | ALDH1A1 (0.48) | ALDH1A1MAPK1TSHRTDP1ZDHHC20 | |
| Allylamine SCHEMBL5391992 | 0.87 | ALDH1A1 (0.47) | ALDH1A1MAPK1TSHRTDP1ZDHHC20 | |
| SCHEMBL8012770 | 0.85 | ZDHHC20 (0.47) | ALDH1A1MAPK1TSHRTDP1ZDHHC20 | |
| SCHEMBL21611 | 0.84 | ZDHHC20 (0.58) | ALDH1A1MAPK1TSHRTDP1ZDHHC20 | |
| SCHEMBL27790589 | 0.84 | ZDHHC20 (0.58) | ALDH1A1MAPK1TSHRTDP1ZDHHC20 | |
| SCHEMBL27642913 | 0.84 | ALDH1A1 (0.44) | ALDH1A1MAPK1TSHRTDP1ZDHHC20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5525692-A | SALT FORMING AN ACRYLIC ESTER OR AMIDE WITH CARBONIC ACID, FORMING AN AMINE SALT CARBONATE MONOMER BEFORE HOMO OR CO-POLYMERIZING, THEN DECARBOXYLATION | KOHJIN CO., LTD. (JP) | 1996-06-11 | — | — | US | disclosed |
| EP-0656372-A1 | SLUDGE DEHYDRATING AGENT | KOHJIN CO. Ltd. (JP) | 1995-06-07 | — | — | EP | disclosed |