Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.31 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407637 | 0.96 | EGFR (0.31) | EGFR | |
| Chloromethane SCHEMBL6934355 | 0.91 | ALDH1A1 (0.31) | TSHR | |
| SCHEMBL93437 | 0.83 | CYP1A2 (0.41) | GABRR3GABRPGABRDHDAC3GABBR2 | |
| SCHEMBL747178 | 0.81 | PAOX (0.45) | GABRR3GABRPGABRDHDAC3GABBR2 | |
| Chloromethane SCHEMBL534115 | 0.79 | CYP1A2 (0.38) | GABRR3GABRPGABRDHDAC3GABBR2 | |
| SCHEMBL15281928 | 0.79 | PAOX (0.48) | GABRR3GABRPGABRDHDAC3GABBR2 | |
| Monoethanolamine SCHEMBL8703802 | 0.78 | CYP1A2 (0.37) | GABRR3GABRPGABRDHDAC3GABBR2 | |
| SCHEMBL6451229 | 0.77 | ACHE (0.33) | — | |
| SCHEMBL543058 | 0.77 | — | — | |
| Sulfuric Acid SCHEMBL9324963 | 0.76 | CYP1A2 (0.35) | GABRR3GABRPGABRDHDAC3GABBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5525692-A | SALT FORMING AN ACRYLIC ESTER OR AMIDE WITH CARBONIC ACID, FORMING AN AMINE SALT CARBONATE MONOMER BEFORE HOMO OR CO-POLYMERIZING, THEN DECARBOXYLATION | KOHJIN CO., LTD. (JP) | 1996-06-11 | — | — | US | disclosed |
| EP-0656372-A1 | SLUDGE DEHYDRATING AGENT | KOHJIN CO. Ltd. (JP) | 1995-06-07 | — | — | EP | disclosed |